Download Alternating Electric Fields Therapy in Oncology: A Practical by Eric T. Wong PDF
By Eric T. Wong
This concise textual content offers an entire evaluate of alternating electrical fields remedy -- often referred to as tumor treating fields -- for glioblastoma and different forms of stable tumor malignancies. Readers are given a basic knowing of this novel anti-cancer remedy modality through studying from scientific trial info in addition to the actual and phone biology results on tumor cells while alternating electrical fields are utilized either in vitro and in vivo.
Chapters illustrate the physics in the back of electrical box propagation in area and different media. this is often via a assessment of our present figuring out of the electrical box results on dividing cells - together with the disruption of cytokinesis, right chromosome segregation and activation at the cellphone floor chaperons that set off immunogenic mobilephone dying. facts from part III trials for the therapy of recurrent and newly clinically determined glioblastomas are integrated, in addition to a few of the ancillary post hoc analyses that have been played through a variety of investigators. the rest of the bankruptcy covers different sturdy tumor malignancies, together with non-small mobile lung melanoma, pancreatic melanoma and ovarian melanoma, as this therapy modality is being utilized to systemic malignancies.
Alternating electrical Fields remedy in Oncology bargains oncologists, neurologists, radiation oncologists, biomedical engineers, cellphone biologists and mitosis researchers the basics wanted for scientific practice.
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Extra resources for Alternating Electric Fields Therapy in Oncology: A Practical Guide to Clinical Applications of Tumor Treating Fields
IEEE Trans Plasma Sci. 2009;37(1):99–106. 25. Gowrishankar TR, Weaver JC. An approach to electrical modeling of single and multiple cells. Proc Natl Acad Sci U S A. 2003;100(6):3203–8. 26. Kotnik T, Miklavčič D. Analytical description of transmembrane voltage induced by electric fields on spheroidal cells. Biophys J. 2000;79(2):670–9. 27. Gowrishankar TR, Stewart DA, Weaver JC. Model of a confined spherical cell in uniform and heterogeneous applied electric fields. Bioelectrochemistry. 2006;68(2):181–90.
A second possible mechanism of action relates to a dielectrophoretic (DEP) effect since the cellular morphology during cytokinesis gives rise to a non-uniform intracellular electric field, with a high gradient at the furrow between the dividing cells exerting forces on polar macromolecules and organelles. Preclinical data demonstrated mitotic arrest, and subsequent apoptosis of different cancer cell lines, as well as structural disruption associated with violent membrane blebbing . TTFields treatment spares quiescent cells and specifically targets cancer cells undergoing mitosis, with a particular optimal frequency of largest inhibitory effect for each cell line tested [7, 13, 16].
A) The electric field in the region between the bilateral ventricles, which are filled with CSF, experiences a higher intensity due to the relatively large conductivity difference compared between CSF and gray matter. (B) The electric field in the region between the bilateral ventricles when gray matter dielectric properties are applied to the bilateral ventricles evens out the differences in conductivity as in A and thus the field intensity is reduced. Note that the white vectors that overlay both maps, representing the direction of the electric field, are essentially pointing in the same direction and the magnitude of the electric fields is different between the two cases.